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Kosin a Chinese subsidiary of Lenovo has recently published a video showing how they modded their Ryzen notebook to run an RTX 3090 from the NVMe M.2 slot. Kosin used their Xiaoxin Air 14 laptop with a Ryzen 5 4600U processor for the demonstration. The systems internal M.2 NVMe SSD was removed and an M.2 to PCIe expansion cable was attached allowing them to connect the RTX 3090. Finally, the laptop housing was modified to allow the PCIe cable to exit the chassis and a desktop power supply was attached to the RTX 3090 for power.
The system booted and correctly detected and utilized the attached RTX 3090. The system performed admirably scoring 14,008 points in 3DMark TimeSpy, for comparison the RTX 3090 paired with a desktop Ryzen 5 3600 scores 15,552, and when paired with a Ryzen 7 5800X scores 17,935. While this is an extreme example pairing an RTX 3090 with a mid-range mobile processor it goes to show the amount of performance achievable over the NVMe M.2 connector. The x4 PCIe 3.0 link of the laptop's M.2 slot could handle a maximum of 4 GB/s, while the x16 PCIe 3.0 slot on previous generation processors offered 16 GB/s, and the new x16 PCIe 4.0 connector doubles that providing 32 GB/s of available bandwidth.